研究業績

I. 英文原著論文(*corresponding author)

2011年

  1. Cho YS, Chen C-H, Hu C, Long J, Ong RTH, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang Y-C, Kwak SH, Ma RCW, Yamamoto K, Adair LS, Aung T, Cai Q, Chang L-C, Chen Y-T, Gao Y, Hu FB, Kim H-L, Kim S, Kim YJ, Lee JJ-M, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, NgDP-K, Tay WT, Tsai F-J, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang T-J, Bao Y, Hedman AK, P Morris AP, McCarthy MI, DIAGRAM consortium36, MuTHER consortium36, Takayanagi R, Park KS, Jia W, Chuang L-M, ChanJCN, Maeda S, Kadowaki T, Lee J-Y, Wu J-Y, TeoYY, Tai ES, Shu XO, Mohlke KL, Kato N, Han B-G, Seielstad M. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011 Dec 11. [Epub ahead of print]. PMID: 22158537
  2. Li H, Kilpelainen T, Liu C, Zhu J, Liu Y, Hu C, Yang Z, Bao W, Cha S, Wu Y, Yang T-L, Sekine A, Choi BY, Yajnik CS, Zhou D, Takeuchi F, Yamamoto K, Chan JC, Mani KR, Been LF, Imamura M, Nakashima E, Lee N, Fujisawa T, Karasawa S, Wen W, Lu W, Chang Y-C, Xiang Y-B, Gao Y, Liu S, Song Y, Kwak SH, Shin HD, Park KS, Fall C, Kim JY, Sham PC, Lam KSL, Zheng W, Shu XO, Deng H-W, Ikegami H, Sanghera DK, Chuang L-M, Liegang Liu, Hu R, Kim Y-M, Daimon M, Hotta K, Jia W, Kooner JS, Chambers JC, Chandak GR, Ma RC, Maeda S, Dorajoo R, Yokota M, Takayanagi R, Kato N, Lin X, Loos RJF*. Association of genetic variation in FTO with risk of obesity and type 2 diabetes in up to 96,551 East and South Asians. Diabetologia. 2011 Nov 23. [Epub ahead of print]. PMID: 22109280
  3. Takeuchi F, Yokota M, Yamamoto K, Nakashima E, Katsuya T, Asano H, Isono M, Nabika T, Sugiyama T, Fujioka A, Awata N, Ohnaka K, Nakatochi M, Kitajima H, Rakugi H, Nakamura J, Ohkubo T, Imai Y, Shimamoto K, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N*. Genome-wide association study of coronary artery disease in the Japanese. Eur J Hum Genet. 2011 Oct 5. doi: 10.1038/ejhg.2011.184 [epub ahead of print] PMID: 21971053
  4. Kato N*, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RT, Nabika T, Gu D, Chang LC, Kokubo Y, Huang W, Ohnaka K, Yamori Y, Nakashima E, Jaquish CE, Lee JY, Seielstad M, Isono M, Hixson JE, Chen YT, Miki T, Zhou X, Sugiyama T, Jeon JP, Liu JJ, Takayanagi R, Kim SS, Aung T, Sung YJ, Zhang X, Wong TY, Han BG, Kobayashi S, Ogihara T, Zhu D, Iwai N, Wu JY, Teo YY, Tai ES, Cho YS, He J. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011, Jun;43(6):531-8. PMID: 21572416
  5. Kooner JS*, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, Been LF, Chia K-S, Dimas AS, Hassanali N, Jafar T, Jowett JBM, Venkatesan R, Rees SD, Takeuchi F, Young R, Aung T, Basit A, Chidambaram M, Das D, Grunberg E, Hedman AK, Hydrie ZI, Islam M, Khor C-C, Kowlessur S, Kristensen MM, Liju S, Lim W-Y, Matthews DR, Liu J, Morris AP, Nica AC, Pinidiyapathirage JM, Prokopenko I, Rasheed A, Samuel M, Shah N, Shera AS, Small KS, Suo C, Wickremasinghe AR, Wong TY, Yang M, Zhang F, DIAGRAM, MuTHER, Abecasis GR, Barnett AH, Caulfield M, Deloukas P, Frayling T, Froguel P, Kato N, Katulanda P, Kelly MA, Liang J, Mohan V, Sanghera DK, Scott J, Seielstad M, Zimmet PZ, Elliott P, Teo YY, McCarthy MI, Danesh J, Tai ES, Chambers JC*. Genome-wide association study in people of South Asian ancestry identifies six novel susceptibility loci for Type 2 Diabetes. Nat Genet. Aug 28;43(10):984-9. PMID: 21874001
  6. Takeuchi F*, Kobayashi S, Ogihara T, Fujioka A, Kato N. Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants. Genome Res. 2011, Jul;21(7):1122-30. PMID: 21441355
  7. Njelekela M, Muhihi A*, Mpembeni R, Masesa Z, Kitamori K, Mori-Yamori M, Kato N, Mtabaji J, Yamori Y. Prevalence of Cardiovascular Disease Risk Factors among Young and Middle-age Men in Urban Mwanza, Tanzania. J Public Health. Accepted.
  8. Takeuchi F, Yamamoto K, Katsuya T, Nabika T, Sugiyama T, Fujioka A, Isono M, Ohnaka K, Fujisawa T, Nakashima E, Ikegami H, Nakamura J, Yamori Y, Yamaguchi S, Kobayashi S, Ogihara T, Takayanagi R, Kato N*. Association of obesity susceptibility genetic variants with type 2 diabetes in the Japanese. Diabetologia. 2011, 54(6):1350-9. PMID: 21369819
  9. Dassanayake AS, Kasturiratne A, Niriella MA, Kalubovila U, Rajindrajith S, De Silva AP, Kato N, Wickremasinghe R and de Silva J*. Prevalence of acanthosis nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome. BMC Research Notes. 2011, 4(1):25. PMID: 21276250
  10. Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N*. The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. Gastroenterology. 2011, 140(5):1513-25. PMID: 21277849
  11. Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N*. Confirmation of ALDH2 as a major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in Japanese. Circ J. 2011, 75(4):911-8. PMID: 21372407

2010年

  1. Ohara-Imaizumi M, Yoshida M, Aoyagi K, Saito T, Okamura T, Takenaka H, Akimoto Y, Nakamichi Y, Takanashi-Yanobu R, Nishiwaki C, Kawakami H, Kato N, Hisanaga S, Kakei M, Nagamatsu S. Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis. PLoS One. 2010 Dec 9;5(12):e15553. PMID: 21151568
  2. Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N*. Blood pressure and hypertension are associated with seven loci showing male-specific interaction with age among the Japanese. Circulation. 2010, 121(21):2302-9. PMID: 20479155
  3. Takeuchi F, Kashida M, Okazaki O, Tanaka Y, Fukuda S, Kashima T, Hosaka S, Hiroe M, Kimura S, Kato N*. Evaluation of pharmacogenetic algorithm for warfarin dose requirements in Japanese patients. Circ J. 2010, 74:977-82. PMID: 20339191
  4. Taniguchi-Yanai K, Koike Y, Hasegawa T, Furuta Y, Serizawa M, Ohshima N, Kato N*, Yanai K*. Identification and characterization of glucocorticoid receptor-binding sites in the human genome. J Recept Signal Transduct Res. 2010, 30(2):88-105. PMID: 20163328
  5. Takeuchi F, Katsuya T, Charkrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N*. Common variants at the GCK, GCKR, G6PC2-ABCB11,and MTNR1B lociare associatedwith fasting glucose in two Asian populations. Diabetologia. 2010, 53(2):299-308. PMID: 19937311

2009年

  1. Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Katsuya T, Miyagishi M, Nakashima N, Nawata H, Nakamura J, Kono S, Takayanagi R, Kato N*. Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes. 2009, 58(7):1690-9. PMID: 19401414
  2. Konoshita T, Kato N, Fuchs S, Mizuno S, Aoyama C, Motomura M, Makino Y, Wakahara S, Inoki I, Miyamori I, Pinet F; the Genomic Disease Outcome Consortium (G-DOC) Study Investigators. Genetic Variant of the Renin-Angiotensin System and Diabetes Influences Blood Pressure Response to Angiotensin Receptor Blocker. Diabetes Care. 2009, 32(8):1485-90. PMID: 19509012
  3. Takeuchi F, Nabika T, Isono M, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Yamori Y, Ogihara T, Kato N*. Evaluation of genetic loci influencing adult height in the Japanese population. J Hum Genet. 2009, 54(12):749-52. PMID: 19834501
  4. Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi F, Fujioka A, Yamori Y, Ogihara T, Kato N. Gene-environmental interaction regarding alcohol metabolizing enzymes in the Japanese general population. Hypertens Res. 2009, 32(3):207-13. PMID: 19262484
  5. Fujimoto T, Miyasaka K, Koyanagi M, Tsunoda T, Baba I, Doi K, Ohta M, Kato N, Sasazuki T, Shirasawa S. Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice. PLoS ONE. 2009, 4:e4240. Epub 2009 Jan 21. PMID: 19156225
  6. Tsuchihashi-Makaya M, Hamaguchi S, Kinugawa S, Yokota T, Goto D, Yokoshiki H, Kato N, Takeshita A, Tsutsui H; JCARE-CARD Investigators. Characteristics and outcomes of hospitalized patients with heart failure and reduced vs preserved ejection fraction. Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD). Circ J. 2009, 73(10):1893-900. PMID: 19644216
  7. Dassanayake AS, Kasthuriratne A, Rajindrajith S, Kalubowila U, Chakrawarthi S, De Silva AP, Makaya M, Mizoue T, Kato N, Wickremasinghe AR, de Silva HJ. Prevalence and risk factors for non-alcoholic fatty liver disease (NAFLD) among adults in an urban Sri Lankan population. J Gastroenterol Hepatol. 2009, 24(7):1284-8. PMID: 19476560
  8. Morii T, Ohno Y, Kato N, Hirose H, Kawabe H, Hirao K, Eguchi T, Maruyama T, Hayashi M, Saito I, Yazaki Y, Saruta T. CD36 SNP is associated with variation in LDL-cholesterol in young Japanese men. Biomarkers. 2009, 14(4):207-12. PMID: 19489681
  9. Tsuchihashi-Makaya M, Kato N, Chishaki A, Takeshita A, Tsutsui H. Anxiety and poor social support are independently associated with adverse outcomes in patients with mild heart failure. Circ J. 2009, 73(2):280-7. PMID: 19096191
  10. Tsukahara T, Nakashima E, Watarai A, Hamada Y, Naruse K, Kamiya H, Nakamura N, Kato N, Hamajima N, Sekido Y, Niwa T, Tomita M, Oiso Y, Nakamura J. Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients. Diabetes Res Clin Pract. 2009, 84(2):179-86. PMID: 19269054
  11. Hanasaki H, Takemura Y, Fukuo K, Ohishi M, Onishi M, Yasuda O, Katsuya T, Awata N, Kato N, Ogihara T, Rakugi H. Fas Promoter Region Gene Polymorphism Is Associated With An Increased Risk For Myocardial Infarction. Hypertens Res. 2009, 32(4):261-4. PMID: 19262492
  12. Takeuchi F, McGinnis R, Bourgeois S, Barnes C, Eriksson N, Soranzo N, Whittaker P, Ranganath V, Kumanduri V, McLaren W, Holm L, Lindh J, Rane A, Wadelius M, Deloukas P. A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. PLoS Genet. 2009 Mar;5(3):e1000433. Epub 2009 Mar 20. PMID: 19300499

2008年

  1. Kato N*, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H. High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet. 2008, 17:617-27. PMID: 18003638
  2. Ochiai Y, Liang YQ, Serizawa M, Kato N*. Dynamic changes of the renin-angiotensin and associated systems in the rat after pharmacological and dietary interventions in vivo. Physiol Genomics. 2008, 35:330-40. PMID: 18796534
  3. Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N*. Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. J Hum Genet. 2008, 53:314-24. PMID: 18259684
  4. Takeuchi F, Serizawa M, Kato N*. HapMap coverage for SNPs in the Japanese population. J Hum Genet. 2008, 53:96-9. PMID: 18043864
  5. Serizawa M, Nabika T, Ochiai Y, Takahashi K, Yamaguchi S, Makaya M, Kobayashi S, Kato N*. Association between PRKCH gene polymorphisms and subcortical silent brain infarction. Atherosclerosis. 2008, 199:340-5. PMID: 18164711
  6. Kato N*, Liang YQ, Ochiai Y, Birukawa N, Serizawa M, Jesmin S. Candesartan-induced gene expression in five organs of stroke-prone spontaneously hypertensive rats. Hypertens Res. 2008, 31:1963-75. PMID: 19015604
  7. Kato N*, Liang YQ, Ochiai Y, Jesmin S. Systemic evaluation of gene expression changes in major target organs induced by atorvastatin. Eur J Pharmacol. 2008, 584:376-89. PMID: 18295756
  8. Koyanagi M, Nakabayashi K, Fujimoto T, Gu N, Baba I, Takashima Y, Doi K, Harada H, Kato N, Sasazuki T, Shirasawa S. ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes. Genomics. 2008, 91:451-7. PMID: 18329245

2007年

  1. Takeuchi F, Yanai K, Inomata H, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N*. Search of type 2 diabetes susceptibility gene on chromosome 20q. Biochem Biophys Res Commun. 2007, 357:1100-6. PMID: 17466274
  2. Jesmin S, Maeda S, Mowa CN, Zaedi S, Togashi H, Prodhan SH, Yamaguchi T, Yoshioka M, Sakuma I, Miyauchi T, Kato N. Antagonism of endothelin action normalizes altered levels of VEGF and its signaling in the brain of stroke-prone spontaneously hypertensive rat. Eur J Pharmacol. 2007, 574:158-71. PMID: 17689527
  3. Fujimoto T, Koyanagi M, Baba I, Nakabayashi K, Kato N, Sasazuki T, Shirasawa S. Analysis of KRAP expression and localization, and genes regulated by KRAP in a human colon cancer cell line. J Hum Genet. 2007, 52:978-84. PMID: 17934691
  4. Wakahara S, Konoshita T, Mizuno S, Motomura M, Aoyama C, Makino Y, Kato N, Koni I, Miyamori I. Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio. Endocrinology. 2007, 148:2453-7. PMID: 17303661

2006年

  1. Konoshita T, Wakahara S, Mizuno S, Motomura M, Aoyama C, Makino Y, Kawai Y, Kato N, Koni I, Miyamori I, Mabuchi H. Tissue gene expression of renin-angiotensin system in human type 2 diabetic nephropathy. Diabetes Care. 2006, 29:848-52. PMID: 16567826
  2. Manabe N, Hoshino A, Liang YQ, Goto T, Kato N, Yamamoto K. Quantum dot as a drug tracer in vivo. IEEE Trans Nanobioscience. 2006, 5:263-7. PMID: 17181025
  3. Takeuchi F, Yamamoto K. Effectiveness of realistic vaccination strategies for contact networks of various degree distributions. J Theor Biol. 2006, 243(1):39-47. PMID: 16860340

2005年

  1. Takeuchi F, Yanai K, Morii T, Ishinaga Y, Taniguchi-Yanai K, Nagano S, Kato N. Linkage disequilibrium grouping of single nucleotide polymorphisms (SNPs) reflecting haplotype phylogeny for efficient selection of tag SNPs. Genetics. 2005, 170:291-304. PMID: 15716494
  2. Watanabe T, Iizuka Y, Liang Y-Q, Inomata H, Gotoda T, Yanai K, Isobe M, Kato N*. Evaluation of insulin resistance linkage to rat chromosome 4 in SHR of a Japanese colony Biochem Biophys Res Commun. 2005, 329: 879-87. PMID: 15752738
  3. Inomata H, Watanabe T, Iizuka Y, Liang Y-Q, Mashimo T, Nabika T, Ikeda K, Yanai K, Gotoda T, Yamori Y, Isobe M, Kato N*. Identification of quantitative trait loci for cardiac hypertrophy in two different strains of the spontaneously hypertensive rat. Hypertens Res. 2005, 28: 273-81. PMID: 16097372

II. 学術集会発表−国際学会・研究会

  1. Matsushita Y, Kishimoto M, Takahashi Y, Kanagawa S, Noda M, Thai SP, Ngoc QN, Hong HPT, Doan LD, Lan VN, Zeng Z-P, Wickremasinghe AR, Naruse M, Kato N, Kajio H. The Cutoff Levels of Waist Circumference for Predicting the Presence of the Clustering of Metabolic Risk Factors in some Asian Populations. IDF World Diabetes Congress 2011, Dubai, UAE, December, 2011.
  2. Horikoshi M, Wiltshire S, Kato N, Asimit J, Rayner N, Robertson N, Takeuchi F, Mahajan A, Teo Y-Y, Zeggini E, Morris A, McCarthy M, T2D-GENES. Trans-ethnic fine-mapping of Type 2 Diabetes susceptibility loci using a “Cosmopolitan” reference panel for imputation. 61st annual meeting of the American Society of Human Genetics and the International Congress of Human Genetics 2011, Montreal, Canada, Oct 14, 2011.
  3. Kato N. GWAS of hypertension-associated disease in the Japanese. 20th KOGO Conference. Osong, Korea, September, 2011.
  4. Horikoshi M, Kato N, Wiltshire S, Asimit J, Rayner NW, Robertson N, Takeuchi F, Teo YY, Zeggini, E, McCarthy M, Morris A, T2D-GENES Consortium. Trans-Ethnic Fine-Mapping of T2D Susceptibility Loci. ADA Annual Meeting 2011, San Diego, USA, June, 2011.
  5. Kato N. Genome-wide exploration of genetic susceptibility to hypertension and associated diseases. 5th Oriental Congress of Cardiology, Shanghai, China, May, 2011.
  6. Kato N. Genome-wide exploration of genetic susceptibility to hypertension and associated diseases. The National University of Singapore, Advanced genomics symposium, Singapore, February, 2011.
  7. Takeuchi F, Kato N. Testing heterogeneity of quantitative trait variance among genotype classes guides fine mapping of association signals. 60th annual meeting of the American Society of Human Genetics, Washington DC, USA, November, 2010.
  8. Kato N. Genetic susceptibility to diabetes and associated diseases in the Japanese. 8th IDF WPR Congress. Busan, Korea, October, 2010.
  9. Kato N. Genome-wide exploration of genetic susceptibility to cardiometabolic diseases. International Congress of Pathophysiology & International SHR Symposium 2010. Montreal, Canada, September, 2010.
  10. Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N. Blood pressure and hypertension are associated with seven loci in the Japanese population. 23rd Scientific Meeting International Society of Hypertension. Vancouver, Canada, September, 2010.
  11. Kato N. Genetic susceptibility to cardiovascular disease and its risk factors in the Japanese. 19th KOGO Conference. Seoul, Korea, September, 2010.
  12. Kato N. Risk of myocardial infarction and stroke among Asians. 10th South East Asia Regional Scientific Meeting of the International Epidemiological Association, Colombo, Sri Lanka, May, 2010.
  13. Takeuchi F, Katsuya T, Yamamoto K, Nabika T, Ranawaka U, Sugiyama T, Fujioka A, Yamori Y, Yamaguchi S, Kobayashi S, Ogihara T, Chakrewarthy S, Wickremasinghe R, and Kato N, for the NIBIO GWA Study and Ragama Health Study. Confirmation of eight loci associated with measures of obesity in two Asian populations with substantial ethnic heterogeneity. 27th annual scientific meeting of the Obesity Society, Washington DC, USA, October, 2009.
  14. Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N for the NIBIO GWA Study. Ethnic diversity in fine mapping of the susceptibility loci G6PC2-ABCB11 for fasting glucose and CDKAL1 for type 2 diabetes. 59th annual meeting of the American Society of Human Genetics, Honolulu, USA, October, 2009.
  15. Konoshita T, Kato N, Fuchs S, Mizuno S, Aoyama C, Motomura M, Kimura T, Fujii M, Makino Y, Wakahara S, Arakawa K, Inoki I, Miyamori I, Pinet P. Genetic Variant of the Renin Angiotensin System Influences Blood Pressure Response to Angiotensin Receptor Blocker. 19th European Meeting on Hypertension, Milan, Italy, June, 2009.
  16. Kato N, Liang Y-Q, Ochiai Y, Serizawa M. Dissection of phenotypic traits associated with metabolic syndrome and positional cloning in the spontaneously hypertensive rat. The 22nd Scientific Meeting International Society of Hypertension, Berlin, Germany, June, 2008.
  17. Kato N, Liang Y-Q, Ochiai Y, Jesmin S. Systemic evaluation of gene expression changes in major target organs induced by atorvastatin. The 22nd Scientific Meeting International Society of Hypertension, Berlin, Germany, June, 2008.
  18. Ochiai Y, Liang Y-Q, Serizawa M, Birukawa N, Jesmin S, Kato N. Exploration of adipose tissue transcriptome network triggered in vivo by an insulin sensitizing agent, pioglitazone. 21st International Mammalian Genome Conference, Kyoto, Japan, October, 2007.
  19. Serizawa M, Liang Y-Q, Yanai K, Ochiai Y, Birukawa N, Jesmin S, Kato N. Compartmentalization of genome network downstream of the glucocorticoid receptor in cultured insulinoma cells and hepatoma cell. 21st International Mammalian Genome Conference, Kyoto, Japan, October, 2007.
  20. Manabe N, Hoshino A, Liang Y-Q, Fujioka K, Kato N, Yamamoto K. Quantum dot as a drug-tracer in vivo. Third International Conference on Advanced Materials and Nanotechnology, Wellington, New Zealand, February, 2007.
  21. Makaya M, Yanai K, Katsuya T, Fujioka A, Yamori Y, Ogihara T, Kato N. Gene-environment interaction regarding ethanol metabolizing enzymes in the Japanese general population. American Heart Association, Scientific Sessions 2006, Chicago, IL, November, 2006.
  22. Ochiai Y, Liang Y-Q, Serizawa M, Yanai K, Kato N. Systematic expression profiling in the major end-organs after pharmacological intervention. 12th International SHR Symposium, Kyoto, Japan, October, 2006.
  23. Makaya M, Yanai K, Katsuya T, Fujioka A, Yamori Y, Ogihara T, Kato N. Gene-environment interaction regarding ethanol metabolizing enzymes in the Japanese general population. 12th International SHR Symposium, Kyoto, Japan, October, 2006.
  24. Kato N, Yanai K, Makaya M, Nabika T, Katsuya T, Fujioka A, Yasuda K, Yamori Y, Kobayashi S, Ogihara T, Yazaki Y. Integrative large-scale candidate gene analysis of atherosclerotic diseases. 21st Scientific Meeting of the International Society of Hypertension, Fukuoka, October, 2006.
  25. Ochiai Y, Liang Y-Q, Serizawa M, Yanai K, Kato N. Dynamic changes of the renin-angiotensin and associated systems in the rat after pharmacological and dietary interventions in vivo. 21st Scientific Meeting of the International Society of Hypertension, Fukuoka, October, 2006.
  26. Kohara Y, Inomata H, Liang Y-Q, Y Ochiai Y, Serizawa M, Yanai K, Kato N. Unraveling genetic susceptibility by constructing 14 consomic strains derived from the spontaneously hypertensive rat strains. 21st Scientific Meeting of the International Society of Hypertension, Fukuoka, October, 2006.
  27. Makaya M, Yanai K, Katsuya T, Fujioka A, Yamori Y, Ogihara T, Kato N. Gene-environment interaction regarding ethanol metabolizing enzymes in the japanese general population. 21st Scientific Meeting of the International Society of Hypertension, Fukuoka, October, 2006.
  28. Inomata H, Yanai K, Nabika T, Nagano S, Isobe M, Kobayashi S, Kato N. Large-scale genetic analysis of stroke in the Japanese. International Stroke Conference 2006, Kissimmee, FL, February, 2006.
  29. Inomata H, Liang YQ, Yanai K, Isobe M, Kato N. Unraveling genetic susceptibility by the construction of eight consomic strains derived from the stroke-prone spontaneously hypertensive rat. International Stroke Conference 2006, Kissimmee, FL, February, 2006.
  30. Manabe N, Hoshino A, Liang Y-Q, Goto T Kato N, Yamamoto K. Quantum dots conjugated with captoril while remained effective in vivo. 2nd International Conference on Advanced Materials and Nanotechnology, Queenstown, February, 2005.

III. 学術集会発表−国内学会・研究会

  1. 加藤規弘. Pathogenesis of Primary Aldosteronism. Primary Aldosteronism Symposium 2011, 東京, 12月, 2011.
  2. 青山千賀子, 加藤規弘, 小川佳宏, 志賀由佳, 河内正治. 当院での術前の抗血小板薬休薬と術後血栓性合併症の実態報告. 第31回日本臨床麻酔学会, 沖縄, 11月, 2011.
  3. 加藤規弘. 高血圧のゲノムワイド関連解析と展望. 第48回日本臨床生理学会総会ランチョンセミナー, 東京, 11月, 2011.
  4. 加藤規弘, CAGE network. 全ゲノム関連解析による、東アジア人での高血圧関連遺伝子の探索:新規メカニズムと人種特異性の同定. 第34回日本高血圧学会総会, 宇都宮, 10月, 2011.
  5. 此下忠志, 加藤規弘, 木村朋子, 藤井美紀, 牧野耕和, 若原成行, 宮森勇. レニン-アンジオテンシン系(RAS)遺伝子型は同系抑制薬の効果を予測し得るか? -RASファルマコジェノミクスのシステマティックレビュー-. 第34回日本高血圧学会総会, 宇都宮, 10月, 2011.
  6. 加藤規弘, 竹内史比古, 山本健, 磯野正人, 勝谷友宏, 杉山卓郎, 並河徹, 藤岡晨宏, 大中佳三, 家森幸男, 山口修平, 小林祥泰, 高柳涼一, 荻原俊男. 日本人での大規模追試研究による、7つの候補遺伝子と血圧値/高血圧との関連の検討. 第34回日本高血圧学会総会, 宇都宮, 10月, 2011.
  7. 此下忠志, 加藤規弘, 宮森勇. 網羅的発現遺伝子解析により抽出された高血圧特異的遺伝子クラスター -高血圧とア ンジオテンシンII消去系遺伝子群発現低下との関連-. 第34回日本高血圧学会総会, 宇都宮, 10月, 2011.
  8. 加藤規弘. 日本人にみられる高血圧関連遺伝子多型. 第51回新潟高血圧談話会, 新潟, 7月, 2011.
  9. 加藤規弘. 高血圧の遺伝子解析の現状. 第73回東京心臓の会, 東京, 6月, 2011.
  10. 此下忠志、加藤規弘、宮森 勇. 網羅的解析による高血圧特異的発現遺伝子の抽出-RAS抑制系遺伝子群の意義. 第84回日本内分泌学会総会, 神戸, 4月, 2011.
  11. 加藤規弘. 動脈硬化性疾患に対する予防戦略. 第81回日本衛生学会学術総会, 東京, 3月, 2011.
  12. 加藤規弘. 世界の稀少疾患対策の動向. 第14回日本内分泌病理学会学術総会, 京都, 10月, 2010.
  13. 竹内史比古, 並河徹, 磯野正人, 勝谷友宏, 杉山卓郎, 山口修平, 小林祥泰, 家森幸男, 荻原俊男, 加藤規弘. 日本人において7つの新規遺伝子座が血圧値および高血圧と関連している. 第33回日本高血圧学会総会, 福岡, 10月, 2010.
  14. 加藤規弘. Post-GWAS時代における高血圧研究の世界的潮流と我が国からの提言. 第33回日本高血圧学会総会, 福岡, 10月, 2010.
  15. 竹内史比古, 加藤規弘. 遺伝子型間での量的形質の異分散性を活用した精密マッピング. 第55回日本人類遺伝学会, 大宮, 10月, 2010.
  16. 加藤規弘. 「統合的生命システム実証学」としてのゲノム疫学研究. 第80回日本衛生学会総会シンポジウム4「生活習慣病を標的とした分子疫学コホート研究の展望」, 仙台, 5月, 2010.
  17. 此下忠志, 加藤規弘, 高橋芳徳, 水野真一, 木村朋子, 藤井美紀, 牧野耕和, 荒川健一郎, 若原成行, 居軒 功, 宮森 勇、G-DOC Study Investigators. 網羅的解析による糖尿病腎症特異的発現遺伝子の抽出-Insulin Regulated Aminopeptidase (IRAP/AT4)の発現低下. 第53回日本糖尿病学会年次学術集会, 岡山, 5月, 2010.
  18. 加藤規弘, 梁一強, Zaidi Ali, 竹内史比古. 劇症型脳卒中易発症モデルラットの作成とポジショナルクローニング. 第32回日本高血圧学会総会, 大津, 10月, 2009.
  19. 此下忠志, 加藤規弘, 水野真一, 本村 誠, 青山千賀子, 木村朋子, 藤井美紀, 牧野耕和, 荒川健一郎, 若原成行, 居軒 功, Sebastien Fuchs, Florence Pinet, 宮森 勇、G-DOC Study Investigators. アンジオテンシン遮断薬responder決定因子としてのレニンアンジオテンシン系遺伝子. 第32回日本高血圧学会総会, 大津, 10月, 2009.
  20. 竹内史比古, 並河徹, 磯野正人, 勝谷友宏, 杉山卓郎, 山口修平, 小林祥泰, 家森幸男, 荻原俊男, 加藤規弘日本人の身長に影響する遺伝子多型の検証. 第54回日本人類遺伝学会, 東京, 9月, 2009.
  21. 加藤規弘. SHR/SHRSPを用いた分子薬理学の展望. 第45回高血圧関連疾患モデル学会学術総会, 東京, 9月, 2009.
  22. 弥富寿麻子, 岡野美江, 加賀朋子, 目﨑悦子, 田中めぐみ, 髙嶋美和, 橋本千草, 堀愛, 小林信之, 加藤規弘. 国立国際医療センターでの臨床研究コーディネーター(MRC)による臨床研究支援の試み. 第9回CRCと臨床試験のあり方を考える会議 2009, 横浜, 9月, 2009.
  23. 此下忠志, 加藤規弘, 牧野耕和, Sebastien Fuchs, Florence Pinet,宮森 勇, G-DOC Study Investigators. レニン遺伝子多型C-5312Tはアンジオテンシン遮断薬の降圧効果に影響する. 第52回日本腎臓学会, 横浜, 6月, 2009.
  24. 竹内史比古, 山本健, 藤澤智巳, 中島英太郎, 大中佳三, 池上博司, 杉山卓郎, 勝谷友宏, 宮岸真, 中島直樹, 名和田新, 中村二郎, 古野純典, 高柳涼一, 加藤規弘. 550Kアレイを用いた日本人2型糖尿病のGenome-Wide Association Studyと遺伝的効果の検証. 第52回日本糖尿病学会年次学術集会, 大阪, 5月, 2009.
  25. 此下忠志, 加藤規弘, 水野真一, 本村 誠, 青山千賀子, 木村朋子, 藤井美紀, 牧野耕和, 荒川健一郎, 若原成行, 居軒 功, Sebastien Fuchs, Florence Pinet, 宮森 勇、G-DOC Study Investigators. アンジオテンシン遮断薬responder決定因子としてのレニンアンジオテンシン系遺伝子と糖尿病. 第52回日本糖尿病学会年次学術集会, 大阪, 5月, 2009.
  26. 加藤規弘, 竹内史比古, 芹澤昌邦, 並河徹, 杉山卓郎, 勝谷友宏, 大久保孝義, 山口修平, 今井潤, 小林祥泰. Genome-Wide Association Studyによるラクナ梗塞と高血圧の感受性遺伝子探索. 第31回日本高血圧学会総会, 札幌, 10月, 2008
  27. 尾留川直子, 梁一強, 王涛, 張燕, 加藤規弘. SHRSP由来のサブコンジェニッック系統を用いた腎障害QTLのポジショナルクローニング. 第31回日本高血圧学会総会, 札幌, 10月, 2008.
  28. Zhang Y, Makaya M, Kastriratne A, Wang T, Miyagishi M, de Silva J, Wickremasinghe AR, Kato N. Type 2 Diabetes is associated with decreased plasma adiponectin levels independently of insulin resistance in South Asians. 第31回日本高血圧学会総会, 札幌, 10月, 2008.
  29. Wang T, Liang Y-Q, Zhang Y, Birukawa N, Kato N. Detection of a rat chromosome 4 region that influences blood pressure using a combination approach. 第31回日本高血圧学会総会, 札幌, 10月, 2008.
  30. Wang T, Liang Y-Q, Zhang Y, Birukawa N, Zhang Y. Kato N. Comprehensive evaluation of gene expression profile induced by six antihypertensive drugs on three end-organs. 第31回日本高血圧学会総会, 札幌, 10月, 2008.
  31. 此下忠志, 木村朋子, 藤井美紀, 牧野耕和, 若原成行, 居軒功, 宮森勇, 加藤規弘, Sebastien Fuchs. 糖尿病性腎症におけるレニン-アンジオテンシン系. 第20回日本糖尿病性腎症研究会, 東京, 12月, 2008.
  32. 此下忠志, 加藤規弘, 牧野耕和, 宮森勇. DNAチップを用いた糖尿病性腎症発現遺伝子の網羅的解析. 第77回北陸糖尿病集談会, 金沢, 12月, 2008.
  33. 此下忠志, 加藤規弘, 水野真一, 本村誠, 青山千賀子, 木村朋子, 牧野耕和, 若原成行, Sebastien Fuch, Florence Pinet, 宮森 勇. アンジオテンシン遮断薬レスポンダー決定因子-レニンアンジオテンシン系遺伝子と糖尿病-. 第76回北陸糖尿病集談会, 金沢, 7月, 2008.
  34. 此下忠志, 牧野耕和, 若原成行, 加藤規弘, 宮森勇. メタボリックシンドロームにおける循環系・組織レニン-アンジオテンシン系亢進. 第51回日本糖尿病学会, 東京, 5月, 2008.
  35. 眞茅みゆき, 三田村昌泰, 笠原茂, 古殿次郎, 上村直実, 加藤規弘. 臨床研究の推進を目的とした臨床研究レジストリおよび臨床データブックの開発と実用. 第9回日本医療情報学会学術大会, 横浜, 11月, 2008.
  36. 岡野美江, 眞茅みゆき, 加藤規弘. 遺伝情報をも対象とした臨床研究における臨床研究コーディネーターの役割. 第7回日本遺伝看護学会, 東京, 9月, 2008.
  37. 田邉真紀人、成瀬光栄、鈴木知子、Zheng-pei Zeng、加藤規弘、岡嶋泰一郎. 中国における肥満症・メタホリックシントロームの実態調査(第2報). 第16回西日本肥満研究会, 宮崎, 7月, 2008.
  38. 眞茅みゆき, 岩嶋義雄, 加藤規弘. 専門医療機関受診者におけるリスクの重積した非メタボリックシンドローム(MS)症例とMS症例の心血管イベント発生率の比較. 第44回日本循環器予防学会・日本循環器管理研究協議会総会, 秋田, 5月, 2008.
  39. 加賀朋子, 今田香, 川路美子, 立入朋子, 目崎悦子, 眞茅みゆき, 上村直実, 加藤規弘. 医師主導型臨床研究を支援する臨床研究コーディネーターの役割:国立国際医療センターでの取り組み. 第72回日本循環器学会総会, 福岡, 3月, 2008.
  40. 加藤規弘, ミレニアムプロジェクト高血圧コンソーシアム. 高密度SNP association studyによる高血圧感受性遺伝子の同定. 第30回日本高血圧学会総会, 那覇, 10月, 2007.
  41. 加藤規弘, 梁一強, 落合義徳, 尾留川直子, 芹澤昌邦, 眞茅みゆき. SHRをモデルとしたメタボリック・シンドローム関連形質の分断化とポジショナル・クローニング. 第30回日本高血圧学会総会, 那覇, 10月, 2007.
  42. 眞茅みゆき, 藤岡晨宏, 勝谷友宏, 荻原俊男, 家森幸男, 加藤規弘. コレステロール逆転送系に関連する14遺伝子と脂質代謝との関連:高血圧罹患の有無と一般集団中での遺伝的効果の検証. 第30回日本高血圧学会総会, 那覇, 10月, 2007.
  43. 河原申弥, 富樫廣子, Subrina Jesmin, Sohel Zaedi, 山口拓, 吉岡充弘, 加藤規弘. エンドセリン受容体遮断はSHRSP大脳皮質における脳血流低下を改善する. 第41回高血圧関連疾患モデル学会学術総会, 大阪, 9月, 2007.
  44. Subrina Jesmin, 富樫廣子, 河原申弥, Sohel Zaedi, 下條信武, 山口直人, 宮内孝, 加藤規弘. Normalization of impairment in VEGF signaling, coronary collateral development and cardiac function in early diabetic rat heart by dual endothelin antagonism. 第41回高血圧関連疾患モデル学会学術総会, 大阪, 9月, 2007.
  45. 中林一彦, 藤本崇弘, 馬場賀, 小柳緑, 顧寧, 土井佳子, 加藤規弘,笹月健彦, 白澤専二. Towards elucidating the transcription network regulated by a novel immune-related transcription factor ZFAT. 第52回日本人類遺伝学会, 9月, 2007.
  46. Serizawa M, Yanai K, Nabika T, Inomata H, Ochiai Y, Makaya M, Kobayashi S, Kato N. Genetic signature for the prevention of stroke in the Japanese population. 第71回日本循環器学会学術集会, 神戸, 3月, 2007.
  47. Ochiai Y, Kohara Y, Inomata H, Liang Y-Q, Serizawa M, Yanai K, Kato N. Unraveling genetic susceptibility by constructing 14 consomic strains derived from the spontaneously hypertensive rat strains. 第71回日本循環器学会学術集会, 神戸, 3月, 2007.
  48. Makaya M, Yanai K, Katsuya T, Fujioka A, Yamori Y, Ogihara T, Kato N. Evaluation of 14 genes involved in reverse cholesterol transport in the Japanese general population. 第71回日本循環器学会学術集会, 神戸, 3月, 2007.
  49. 柳内和幸, 柳内圭子, 芹澤昌邦, 小池淑子, 落合義徳, 加藤規弘. ゲノムスケールでの転写因子標的配列の系統的な同定法の開発. 日本分子生物学会2006フォーラム, 名古屋, 12月, 2006.
  50. 芹澤昌邦, 柳内和幸, 柳内圭子, 小池淑子, 加藤規弘. ラットゲノムからのグルココルチコイド受容体結合配列の系統的な同定と解析. 日本分子生物学会2006フォーラム, 名古屋, 12月, 2006.
  51. 柳内圭子, 柳内和幸, 小池淑子, 芹澤昌邦, 加藤規弘. ヒトゲノムからのエストロゲン受容体結合配列の系統的な同定と解析. 日本分子生物学会2006フォーラム, 名古屋, 12月, 2006.
  52. 藤岡晨宏, 眞茅みゆき, 加藤規弘. 尼崎市民健康開発センターの検診受診者における高血圧の発症頻度および発症関連要因の検討. 第65回日本公衆衛生学会総会、富山, 10月, 2006.
  53. 落合義徳, 梁一強, 猪又兵衛, 芹澤昌邦, 柳内和幸, 加藤規弘, 矢崎義雄. レニン-アンジオテンシン-アルドステロン系遺伝子群の臓器および外的刺激に特異的な発現変動. 第14回分子高血圧研究会, 東京, 10月, 2005.
  54. 猪又兵衛, 梁一強, 落合義徳, 芹澤昌邦, 磯部光章, ,柳内和幸, 加藤規弘. コンジェニックラットにおけるQTLの検証とfine mappingのための戦略的アプローチ. 第41回高血圧関連疾患モデル学会学術総会, 札幌, 9月, 2005.
  55. 落合義徳, 梁一強, 猪又兵衛, 芹澤昌邦, 柳内和幸, 加藤規弘. DNAマイクロアレイ法を用いた降圧剤応答性遺伝子群の検出—ファーマコゲノミクスへの展開. 第41回高血圧関連疾患モデル学会学術総会, 札幌, 9月, 2005.
  56. 加藤規弘, 柳内和幸, 竹内史比古, 猪又兵衛, 眞茅みゆき, 柳内圭子, 長野忍, 並河徹, 勝谷友宏, 藤岡晨宏, 安田和基, 家森幸男, 小林祥泰, 荻原俊男, 矢崎義雄. 動脈硬化性疾患に関する複合的かつ大規模な候補遺伝子解析. 第28回日本高血圧学会総会, 旭川, 9月, 2005.
  57. 猪又兵衛, 梁一強, 落合義徳, 芹澤昌邦, 磯部光章, 柳内和幸, 加藤規弘. SHRSP由来の8コンソミック系統を用いた、高血圧関連疾患の組織的な遺伝子解析. 第28回日本高血圧学会総会, 旭川, 9月, 2005.
  58. 猪又兵衛, 梁一強, 落合義徳, 芹澤昌邦, 磯部光章, 柳内和幸, 加藤規弘. コンジェニックラットにおけるQTLの検証とfine mappingのための戦略的アプローチ. 第28回日本高血圧学会総会, 旭川, 9月, 2005.
  59. 落合義徳, 梁一強, 猪又兵衛, 芹澤昌邦, 柳内和幸, 加藤規弘. DNAマイクロアレイ法を用いた降圧剤応答性遺伝子群の検出:ファーマコゲノミクスへの展開. 第28回日本高血圧学会総会, 旭川, 9月, 2005.
  60. 落合義徳, 梁一強, 猪又兵衛, 芹澤昌邦, 柳内和幸, 加藤規弘. レニンーアンジオテンシン系遺伝子の網羅的発現解析. 第28回日本高血圧学会総会, 旭川, 9月, 2005.
  61. 柳内和幸, 長野忍, 芹澤昌邦, 小池淑子, 落合義徳, 柳内圭子 竹内史比古, 加藤規弘. 代謝性疾患の個別化医療に向けた統合データベース構築:JMDBase. 第28回日本高血圧学会総会, 旭川, 9月, 2005.
  62. 柳内和幸, 並河徹, 竹内史比古, 猪又兵衛, 小林祥泰, 加藤規弘. 2つの新規な脳卒中感受性遺伝子—PDE4DとALOX5AP—の脳硬塞の病型分類を考慮した日本人での評価. 第28回日本高血圧学会総会, 旭川, 9月, 2005.
  63. 真鍋法義、星野昭芳、梁一強、後藤知将、加藤規弘、山本健二. Quantum dotsと薬剤の結合によるn vivoでの効果. 日本薬学会第125年会, 東京, 3月, 2005.